6-I-CPS exerted estrogenic effect through ER-mediated pathway.
NADA, capsazepine, dihydrocapsaicin, TSA, and capsaicin suppressed ER transactivation activity in MVLN cells.
Aryl halogenation and long lipophilic carbon chain of capsaicin template may result in increased or depressed ER伪 transcription activity.
Species selectivity of ER伪 transcription activity due to receptor polymorphism cannot be neglected for capsaicin analogues.