Impact of carotid atherosclerosis loci on cardiovascular events
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- 作者：Daiane Hemericha ; b ; D.Hemerich@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author ; daianehemerich@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Sander W. van der Laanc ; Vinicius Tragantea ; Hester M. den Ruijterc ; g ; Gert Jan de Borstd ; Gerard Pasterkampa ; e ; Paul I.W. de Bakkerf ; g ; Folkert W. Asselbergsa ; h ; i ; F.W.Asselbergs@umcutrecht.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Atherosclerosis ; Single-nucleotide polymorphisms ; Carotid intima-media thickness ; Plaque
- 刊名：Atherosclerosis
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：243
- 期：2
- 页码：466-468
- 全文大小：194 K
文摘
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We tested 6 variants related to carotid atherosclerosis for replication and association to other vascular beds in SMART.
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We replicated the association of 4 SNPs (p < 0.05), with a direction of effect similar to previous reports (binomial p = 0.03).
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One SNP was associated with CAD (odds ratio = 1.24, 95% C.I. 1.08–1.42, p = 2 × 10−3), adding evidence to previous reports.
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A genetic risk score based on cIMT-related SNPs was associated with cIMT (p = 1 × 10−3).
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The genetic risk score was not associated to clinical events during follow-up (p = 0.86).