PLGA nanofibers blended with designer self-assembling peptides for peripheral neural regeneration
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- 作者：Manasa NuneAuthor Vitae ; Uma Maheswari KrishnanAuthor Vitae ; Swaminathan Sethuraman ; swami@sastra.edu" class="auth_mail" title="E-mail the corresponding authorAuthor Vitae
- 关键词：Peripheral nerve injury ; Electrospun nanofibers ; Self-assembling peptides ; Poly(l-lactide-co-glycolide) (PLGA) ; RADA16-I-BMHP1 peptide
- 刊名：Materials Science & Engineering C
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：62
- 期：Complete
- 页码：329-337
- 全文大小：1393 K
文摘
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A novel blended scaffold of polymer PLGA and designer self-assembling peptide RADA16-I-BMPH1 was designed
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The peptide retained the self-assembling features and formed rod like nanostructures on top of PLGA nanofibers
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PLGA-peptide scaffolds have promoted the Schwann cell bipolar extension and elongation in a significant manner
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Gene expression of few neural developmental markers was significantly upregulated in the PLGA-peptide scaffolds
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This combination of nanostructural & bioactive cues would enhance the axonal regeneration capacity of Schwann cells