Simulation of the M13 life cycle I: Assembly of a genetically-structured deterministic chemical kinetic simulation

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• 作者：Steven W. Smeal^a ; Margaret A. Schmitt^a ; Ronnie Rodrigues Pereira^a ; Ashok Prasad^a ; John D. Fisk^a ; ^b ; ^c ; ^{nickfisk@colostate.edu}
• 关键词：M13 bacteriophage ; Computational biology ; Virus life cycle ; Systems biology ; Genetically-structured simulation
• 刊名：Virology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：500
• 期：Complete
• 页码：259-274
• 全文大小：1730 K
• 卷排序：500

文摘

Available quantitative data on M13 biology assembled as a chemical kinetic simulation. Model reproduces holistic behavior of infection from DNA entry to progeny release. Simulation matches experimentally-measured DNA, RNA, protein and progeny levels.