Toxicokinetic models and related tools in environmental risk assessment of chemicals

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• 作者：Audrey Grech^a ; ^b ; Cé ; line Brochot^a ; Jean-Lou Dorne^c ; Nadia Quignot^b ; Fré ; dé ; ric Y. Bois^a ; Ré ; my Beaudouin^a ; ^{remy.beaudouin@ineris.fr}
• 关键词：Environmental risk assessment ; Toxicokinetics ; Internal dose ; Bioconcentration factor ; PBTK
• 刊名：Science of The Total Environment
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：578
• 期：Complete
• 页码：1-15
• 全文大小：853 K
• 卷排序：578

文摘

State-of-the-art of toxicokinetic models in environmental risk assessment Empirical compartment models were more developed than mechanistic models. Models were mostly developed for aquatic species, in particular for fish. Models were applied to a diversity of organic and inorganic compounds classes. Further research needs: developing mechanistic models integrating confounding factors.