Catalytic enantioselective allylboration of propargylic aldehydes
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- 作者：Urmibhusan Bhakta ; Erin Sullivan ; Dennis G. Hall
- 关键词：Propargylic alcohols ; Brø ; nsted acid ; Enantioselective catalysis ; Crotylation ; Homoallylic alcohols
- 刊名：Tetrahedron
- 出版年：21 January, 2014
- 年：2014
- 卷：70
- 期：3
- 页码：678-683
- 全文大小：1472 K
文摘
Homoallylic propargylic alcohols are important building blocks in natural product synthesis. This moiety can be transformed into various other structures by performing other known transformations, which can in turn lead to the synthesis of biologically useful compounds. Herein, a methodology based on Lewis acid assisted Br酶nsted acid catalysed allylboration of propargylic aldehydes is described. A detailed optimization study followed by a thorough examination of substrate scope have been explored.