Oxidative stress and mitochondrial protein quality control in aging
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- 作者：Eirini Lionaki ; Nektarios Tavernarakis
- 关键词：mtPQC ; mitochondrial protein quality control ; TCA ; tricarboxylic acid ; mtDNA ; mitochondrial DNA ; TPR ; tetratricopeptide repeat ; Hsp ; heat-shock protein ; TOM ; translocase of the outer membrane ; TIM ; translocase of the inner membrane ; MTS ; mitochondrial targeting signal ; PAM ; presequence translocase associated motor ; IMS ; intermembrane space ; MPP ; mitochondrial processing peptidase ; IMP ; inner membrane peptidase ; AAA ; ATPases Associated with various cellular activities ; FtsH ; Filament forming temp
- 刊名：Journal of Proteomics
- 出版年：30 October, 2013
- 年：2013
- 卷：92
- 期：Complete
- 页码：181-194
- 全文大小：688 K
文摘
Mitochondrial protein quality control incorporates an elaborate network of chaperones and proteases that survey the organelle for misfolded or unfolded proteins and toxic aggregates. Repair of misfolded or aggregated protein and proteolytic removal of irreversibly damaged proteins are carried out by the mitochondrial protein quality control system. Initial maturation and folding of the nuclear or mitochondrial-encoded mitochondrial proteins are mediated by processing peptidases and chaperones that interact with the protein translocation machinery. Mitochondrial proteins are subjected to cumulative oxidative damage. Thus, impairment of quality control processes may cause mitochondrial dysfunction. Aging has been associated with a marked decline in the effectiveness of mitochondrial protein quality control. Here, we present an overview of the chaperones and proteases involved in the initial folding and maturation of new, incoming precursor molecules, and the subsequent repair and removal of oxidized aggregated proteins. In addition, we highlight the link between mitochondrial protein quality control mechanisms and the aging process.
This article is part of a Special Issue entitled: Posttranslational Protein modifications in biology and Medicine.