Isolation of a cDNA encoding a widely expressed novel zinc finger protein with the LeR and KRAB-A domains
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- 作者：Yokoyama ; Masahiro ; Nakamura ; Motonao ; Okubo ; Kousaku ; Matsubara ; Kenichi ; Nishi ; Yoshisuke ; et. al.
- 关键词：Human ; cDNA sequence ; Zinc finger motif ; LeR domain ; KRAB-A domain
- 刊名：Biochimica et Biophysica Acta (BBA)/Gene Structure and Expression
- 出版年：1997
- 出版时间：July 17, 1997
- 年：1997
- 卷：1353
- 期：1
- 页码：13-17
- 全文大小：506 K
文摘
We have isolated a human cDNA clone representing a novel human gene. The predicted 683-amino-acid protein, designated FPM315, contains nine C2H2-type zinc finger motifs and two regions homologous to the LeR domain, a finger-associated structural domain, and the A element of the Kruppel-associated box (KRAB) domain involved in transcriptional repression. The FPM315 mRNAs were expressed in all human tissues so far examined. A cross-species genomic hybridization indicates that the FPM315 gene is highly conserved among eukaryotes. These data suggest that FPM315 might play an important role in basic cellular processes.