Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions
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- 作者：Faisal Aziza ; Xiaoqi Wangb ; Jiwei Liuc ; jiweiliudl@126.com" class="auth_mail" title="E-mail the corresponding author ; Qiu Yana ; yanqiu63@126.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：H. pylori ; Helicobacter pylori ; CagA ; cytotoxin associated antigen A ; DAPI ; 4-6-diamidino-2-phenylindole ; ELISA ; enzyme-linked immunosorbent assay ; FACS ; fluorescence activated cell sorting ; FUTs ; fucosyltransferases ; FUT4 ; fucosyltransferase IV ; HSF1 ; heat Shock factor 1 ; ICC ; immunocytochemistry ; IFC ; immunofluorescence ; IRAC ; International Research Agency for Cancer ; LeY ; Lewis Y ; PARP ; poly (ADP-ribose) polymerase ; MAPKs ; mitogen-activated protein kinases ; siRNA ; small interfering RNA ; SP1
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：158-166
- 全文大小：1352 K
文摘
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Conventional chemotherapy has limited efficacy to treat gastric cancer.
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H. pylori CagA upregulated FUT4 with SP1 and HSF1 transcriptions.
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Ginsenoside Rg3 (herbal medicine) induced cell apoptosis with FUT4 downregulation.
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Rg3 induced apoptosis with FUT4 inhibition via SP1 and HSF1 transcription regulation.
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Herbal therapy is a better strategy to treat gastric cancer with low toxicity.