Interaction between gene A-positive Helicobacter pylori and human leukocyte antigen II alleles increase the risk of Graves disease in Chinese Han population: An association study

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• 作者：Yipeng Wang ; Siying Zhu ; Yancheng Xu ; Xintao Wang ; Youqing Zhu
• 关键词：CI ; confidence intervals ; CagA ; cytotoxin-associated gene A ; dNTP ; deoxy-ribonucleoside triphosphate ; EDTA ; Ethylene Diamine Tetraacetic Acid ; FT3 ; free triiodothyronine ; FT4 ; free thyroxine ; GD ; Graves disease ; HLA ; human leukocyte antigen ; H. pylori ; He
• 刊名：Gene
• 出版年：2013
• 出版时间：15 November, 2013
• 年：2013
• 卷：531
• 期：1
• 页码：84-89
• 全文大小：385 K

文摘

Objective

The current study explored the correlation of Helicobacter pylori and the polymorphisms of human leukocyte antigen II (HLA-II) alleles with Graves disease (GD).

Methods

A total of 216 patients with GD were recruited. 102 healthy volunteers constituted the control group. Levels of H. pylori immunoglobulin G (IgG) antibodies and H. pylori cytotoxin-associated gene A (CagA) IgG antibodies were detected using enzyme-linked immunosorbent assays. Molecular typing of the HLA-II alleles was conducted using polymerase chain reaction with sequence specific primers.

Results

H. pylori, particularly CagA-positive strains, HLA-DQA1*0201, and HLA-DQA1*0501 were associated with GD (P = 0.015, OR = 1.811; P = 0.000, OR = 3.085; P = 0.000, OR = 0.315; and P = 0.004, OR = 2.844, respectively). Patients with CagA-positive H. pylori and negative HLA-DQA1*0201 or positive HLA-DQA1*0501 were more likely exposed to GD compared with those with only one of these indices.

Conclusion

CagA-positive H. pylori, negative HLA-DQA1*0201, or positive HLA-DQA1*0501 may increase the risk of GD.