Tfh cells are a distinct T helper lineage that provides help to B cells.
Tfh cell differentiation is a multistage, multifactorial process with significant heterogeneity.
Tfh cells can acquire characteristic overlapping with other Th effector cells.
Tfh cells are a major source of IL-4 which is differentially regulated compared to Th2 cells.
Tfh cells are implicated in a majority of diseases including immune-mediated disorders.