The efficacy of aripiprazole in the treatment of multiple symptom domains in patients with acute schizophrenia: A pooled analysis of data from the pivotal trials

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• 作者：John M. Kane ; Sheila Assun&#xe7 ; &#xe3 ; o-Talbott ; James M. Eudicone ; Andrei Pikalov ; Richard Whitehead ; David T. Cr ; all
• 关键词：Aripiprazole ; Schizophrenia ; Item analysis
• 刊名：Schizophrenia Research
• 出版年：2008
• 出版时间：October 2008
• 年：2008
• 卷：105
• 期：1-3
• 页码：208-215
• 全文大小：776 K

文摘

Objective

To examine the efficacy of aripiprazole across symptoms in patients with acute exacerbation of schizophrenia or schizoaffective disorder.

Methods

Data were pooled from five, 4–6-week acute studies. PANSS Total, Positive, Negative, and General Psychopathology Subscale improvements were analyzed, as well as all 30 individual PANSS items.

Results

Aripiprazole had statistically significant decreases versus placebo on PANSS subscales at Week 4, similar to those seen with haloperidol. Aripiprazole-treated patients also showed significant decreases versus placebo in 26 of the 30 PANSS items (all p < 0.05).

Conclusion

Aripiprazole demonstrates statistically and clinically significant efficacy across a range of symptoms in schizophrenia.