Stem and Progenitor Cell-Derived Astroglia Therapies for Neurological Diseases

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• 作者：Chen Chen¹ ; ² ; Albert Chan³ ; Han Wen¹ ; ² ; Seung-Hyuk Chung⁴ ; Wenbin Deng¹ ; ² ; ^{wbdeng@ucdavis.edu" class="auth_mail" title="E-mail the corresponding author} ; Peng Jiang¹ ; ² ; ⁵ ; ^{peng.jiang@unmc.edu" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Trends in Molecular Medicine
• 出版年：2015
• 出版时间：November 2015
• 年：2015
• 卷：21
• 期：11
• 页码：715-729
• 全文大小：2083 K

文摘

Astroglia are a major cellular constituent of the central nervous system (CNS) and play crucial roles in brain development, function, and integrity. Increasing evidence demonstrates that astroglia dysfunction occurs in a variety of neurological disorders ranging from CNS injuries to genetic diseases and chronic degenerative conditions. These new insights herald the concept that transplantation of astroglia could be of therapeutic value in treating the injured or diseased CNS. Recent technological advances in the generation of human astroglia from stem and progenitor cells have been prominent. We propose that a better understanding of the suitability of astroglial cells in transplantation as well as of their therapeutic effects in animal models may lead to the establishment of astroglia-based therapies to treat neurological diseases.