Biimidazoline ligands for palladium-catalyzed asymmetric allylic alkylation

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• 作者：Xin-Qi Hao ; Ya-Nan Dong ; Biao Gao ; Ke Li ; Xue-Mei Zhao ; Yan Xu ; Mao-Ping Song ; ^{maopingsong@zzu.edu.cn" class="auth_mail" title="E-mail the corresponding author}
• 刊名：Tetrahedron: Asymmetry
• 出版年：2015
• 出版时间：15 December 2015
• 年：2015
• 卷：26
• 期：23
• 页码：1360-1368
• 全文大小：914 K

文摘

A practical one-pot method for the synthesis of biimidazoline has been developed. A variety of biimidazolines were prepared smoothly under mild conditions and were evaluated in Pd-catalyzed asymmetric allylic alkylation of 1,3-diaryl-2-propenyl acetate with malonate. The catalytic system gave the desired adducts in good yield and with excellent enantioselectivities (up to 97% ee).