Enzyme promiscuity: first protein-catalyzed Morita–Baylis–Hillman reaction

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• 作者：Manfred T. Reetz ; Ré ; gis Mondiè ; re ; José ; Daniel Carballeira
• 关键词：Baylis&#x2013 ; Hillman reactions ; Enzymes and enzyme reactions ; Proteins ; Asymmetric reactions ; Enantioselection
• 刊名：Tetrahedron Letters
• 出版年：2007
• 出版时间：5 March 2007
• 年：2007
• 卷：48
• 期：10
• 页码：1679-1681
• 全文大小：120 K

文摘

The Morita–Baylis–Hillman reaction of cyclohexenone and p-nitro benzaldehyde is catalyzed by carrier proteins such as serum albumins or enzymes such as certain lipases, conversion of up to 35 % and enantioselectivities of up to 19 % being observed.