文摘
The asymmetric catalytic aza-Moritax2013;Baylisx2013;Hillman reaction of N-sulfonated imines with α,β-unsaturated ketones has been successfully conducted by using chiral bifunctional phosphine amides as catalysts. A series of new chiral bifunctional phosphine amides were designed, synthesized, and systematically studied for this asymmetric reaction. The corresponding aza-MBH adducts were obtained in good yields (75x2013;99 % ) and up to very good enantiomeric excesses (51x2013;95 % ee) under mild conditions.