Aza-Morita–Baylis–Hillman-type reactions: highly enantioselective organocatalytic addition of unmodified α,β-unsaturated aldehydes to N-Boc protected imines

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• 作者：Jan Vesely ; Pawel Dziedzic ; Arm ; o Có ; rdova
• 关键词：Indazoles ; Hydrazones ; Salicyaldehyde ; Hydrazine hydrochloride
• 刊名：Tetrahedron Letters
• 出版年：2007
• 出版时间：24 September 2007
• 年：2007
• 卷：48
• 期：39
• 页码：6900-6904
• 全文大小：154 K

文摘

Highly enantioselective catalytic routes to Boc protected aza-Morita–Baylis–Hillman-type products are presented. The organocatalytic asymmetric reactions between unmodified α,β-unsaturated aldehydes and N-Boc protected aryl imines proceed with excellent chemo- and enantioselectivity to give the corresponding compounds in good yields with 97–99 % ee.