Chiral phosphinothiourea-catalyzed asymmetric Morita–Baylis–Hillman reactions of acrylates with aromatic aldehydes
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- 作者：Kui Yuan ; Hong-Liang Song ; Yinjun Hu ; Xin-Yan Wu
- 关键词：Chiral phosphinothiourea ; Acrylate ; Asymmetric organocatalysis ; Enantioselective Morita– ; Baylis– ; Hillman reaction
- 刊名：Tetrahedron
- 出版年：2009
- 出版时间：26 September 2009
- 年：2009
- 卷：65
- 期：39
- 页码：8185-8190
- 全文大小：237 K
文摘
A series of chiral bifunctional phosphinothioureas were synthesized and applied to the enantioselective Morita–Baylis–Hillman reaction of aromatic aldehydes with acrylates. In the presence of 8 mol % of organocatalyst 2e, the Baylis–Hillman adducts were obtained in good enantioselectivities and up to 96 % yield under mild reaction conditions.