Design, synthesis, and evaluation of asymmetric EF24 analogues as potential anti-cancer agents for lung cancer
文摘
Novel asymmetrical EF24 analogues are synthesized. Compound 81 shows greater antitumor activity than EF24, and is a valuable candidate for anti-lung cancer therapy. Compound 81 induces lung cancer cells apoptosis by inhibiting NF-κB signaling, and activating ROS-mediated JNK pathway.