Transition metal complexes of asymmetrical aroyl-hydrazone ligand: Syntheses, structures, DNA binding and cleavage studies

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• 作者：Wang Jing-lin ; Zhao Ya-qin ; Yang Bin-sheng
• 关键词：Aroyl-hydrazone complex ; Crystal structure ; DNA-binding ; DNA cleavage
• 刊名：Inorganica Chimica Acta
• 出版年：1 January, 2014
• 年：2014
• 卷：409
• 期：part_PB
• 页码：484-496
• 全文大小：3678 K

文摘

Syntheses and crystal structures of aroyl-hydrazone ligands and their transition metal complexes (E)-N鈥?(2-hydroxybenzylidene)-1-methyl-4-nitro-1H-pyrrole-2-carbohydrazide (H₂1), [Cu^II(H1)Cl] (2), [Fe^III(H1)Cl₂(MeOH)] (3), [Mn^III(1)(渭-OMe)(MeOH)]₂ (4), [V^VO(1)(OMe)] (5), Et₃NH[V^VO₂(1)] (6), [Co^II(H1)(渭-Cl)(H₂O)]₂ (7) and [Co^II(1)₂] (7鈥? are reported in this paper. The binding abilities of the compounds with calf thymus DNA are measured by using UV-Vis and fluorescence spectra. The apparent binding constant (K_obs = (1.66 卤 0.21) 脳 10⁴ M^鈭?) and rate constant (k_obs = 3.62 卤 0.17 h^鈭?) of 2 with CT-DNA is calculated, respectively. The quenching constants (K_q) 3.52 脳 10⁴ for 3, 1.97 脳 10⁴ for 4, 5.94 脳 10³ for 2, 3.32 脳 10³ for 7, 1.64 脳 10³ for 5, 1.55 脳 10³ M^鈭? for H₂1 are determined, respectively, using ethidium bromide, as fluorescence probe. Agarose gel electrophoresis studies indicated that the complexes cleave plasmid pBR322 DNA by a hydrolytic mechanism.