Influence of reduced glutathione on end-joining of DNA double-strand breaks: Cytogenetical and molecular approach

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• 作者：Nitin Ghoshal^a ; Sheetal Sharma^b ; Atanu Banerjee^a ; Sillarine Kurkalang^a ; Sathees C. Raghavan^b ; Anupam Chatterjee^a ; ^{chatterjeeanupam@hotmail.com}
• 关键词：DNA double strand break ; Radiation ; Chromosome aberrations ; Exchange aberrations ; Glutathione ; End-joining efficiency ; Cell-free assay system
• 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：795
• 期：Complete
• 页码：1-9
• 全文大小：1798 K
• 卷排序：795

文摘

DNA lesions induced by Blem and radiation interact well and form higher frequency of exchange aberrations. Cellular level of glutathione does influence such interaction of DNA lesions. Oligomer-based cell-free assay system demonstrated better end-joining efficiency at higher level of endogenous GSH.