Multi-omics approach to study global changes in a triclosan-resistant mutant strain of Acinetobacter baumannii ATCC 17978

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• 作者：Dinesh M. Fernando^a ; Patrick Chong^b ; Manu Singh^a ; Victor Spicer^c ; Mark Unger^a ; Peter C. Loewen^a ; Garrett Westmacott^b ; Ayush Kumar^a ; ^d ; ^{Ayush.Kumar@umanitoba.ca}
• 关键词：Genomics ; RNA-Seq ; Proteomics ; Global gene response
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：1
• 页码：74-80
• 全文大小：1032 K
• 卷排序：49

文摘

Use of genome sequencing, RNA-Seq and proteomics to understand the impact of triclosan resistance on A. baumannii. A. baumannii responds to triclosan by altering gene expression. Altered expression of genes involved in antibiotic resistance and fatty acid and amino acid metabolism.