A phase 2b randomized, controlled trial of the efficacy of the GMZ2 malaria vaccine in African children
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- 作者：Sodiomon B. Sirimaa ; 1 ; Benjamin Mordmü ; llerb ; 1 ; Paul Milliganc ; Ulysse Ateba Ngoab ; d ; Fred Kirondee ; Frank Atugubaf ; Alfred B. Tionoa ; Saadou Issifoub ; d ; Mark Kaddumukasae ; Oscar Bangref ; Clare Flachc ; Michael Christianseng ; Peter Bangg ; Roma Chilengih ; Sø ; ren Jepseng ; Peter G. Kremsnerb ; d ; Michael Theiseng ; i ; mth@ssi.dk" class="auth_mail" title="E-mail the corresponding author ; The GMZ2 Trial Study Group2 ; Alphonse Oué ; draogoj ; Dé ; siré ; Kargougouj ; Issa Né ; bié ; j ; Siaka Dé ; bé ; j ; Amidou Diarraj ; Edith Bougoumaj ; Aurore B. Hounkpatink ; l ; Ayola Akim Adegnikak ; l ; Bertrand Lellk ; l ; Fanny Joannyk ; l ; Yabo Josiane Honkpehedjik ; l ; Jean Claude Dejon Agobek ; l ; Meral Esenk ; Anthony Ajuak ; l ; Victor Asoalan ; Thomas Anyorigiyan ; Nana Akosua Ansahn ; William Buwembom ; Edison Mworozim ; Musa Sekikubom ; Ismaela Abubakaro ; Kalifa Bojango ; Ramadhani Noorq ; Brenda Okechp ; Dawit A. Ejigup
- 关键词：Phase 2 clinical trial ; GMZ2 ; GLURP ; MSP3 ; Vaccine ; Antibody ; Efficacy ; Plasmodium falciparum
- 刊名：Vaccine
- 出版年：2016
- 出版时间：31 August 2016
- 年：2016
- 卷：34
- 期：38
- 页码：4536-4542
- 全文大小：578 K
文摘
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The GMZ2 fusion protein consist of the non-repeat region of falciparum GLURP genetically fused to a msp3 fragment.
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The GMZ2 fusion protein elicited functional antibodies in phase 1 studies.
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In the ATP analysis, vaccine efficacy adjusted for age and site was 14% (95% CI: 3.6%, 23%).
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Vaccine efficacy was higher in older children.
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In GMZ2-vaccinated children, the incidence of malaria decreased with increasing vaccine-induced anti-GMZ2 IgG concentration.