Peripheral and central neuronal ATF3 precedes CD4 + T-cell infiltration in EAE
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- 作者：Noé ; mie Frezel1 ; nmfrezel@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Fabien Sohet f.sohet@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; Richard Daneman rdaneman@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; Allan I. Basbaum ; allan.basbaum@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Joao M. Braz joao.braz2@ucsf.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Experimental allergic encephalomyelitis ; Demyelination ; ATF3 ; Dorsal root ganglion ; Spinal cord ; Myelin oligodendrocyte glycoprotein ; Pertussis toxin
- 刊名：Experimental Neurology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：283
- 期：part_PA
- 页码：224-234
- 全文大小：2729 K
文摘
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MOG induces ATF3 expression and CD4 T-cell infiltration in CNS and sensory ganglia.
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ATF3 expression and T-cell invasion precede motor deficits.
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ATF3 induction precedes T-cell invasion in CNS and sensory ganglia.
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ATF3 induction in sensory neurons is nerve injury-independent.
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Adjuvants alone induce ATF3, but not T-cell infiltration, in sensory ganglia.