BRAF-mutated cells activate GCN2-mediated integrated stress response as a cytoprotective mechanism in response to vemurafenib

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• 作者：Ikuko Nagasawa^a ; ^b ; Kazuhiro Kunimasa^a ; Satomi Tsukahara^a ; Akihiro Tomida^a ; ^b ; ^{akihiro.tomida@jfcr.or.jp}
• 关键词：Vemurafenib ; BRAF ; Integrated stress response ; GCN2 ; ATF4
• 刊名：Biochemical and Biophysical Research Communications
• 出版年：2017
• 出版时间：22 January 2017
• 年：2017
• 卷：482
• 期：4
• 页码：1491-1497
• 全文大小：1824 K
• 卷排序：482

文摘

Vemurafenib rapidly induced ATF4 through GCN2 activation in BRAF-mutated cells. Induction of the ISR by vemurafenib occurred independently of PERK. ATF4 silencing sensitized BRAF-mutated cells to vemurafenib.