Deletion of Atf6α enhances kainate-induced neuronal death in mice
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- 作者：Dai Kezukaa ; Mika Tkarada-Iemataa ; Tsuyoshi Hattoria ; Kazutoshi Morib ; d ; Ryosuke Takahashic ; d ; Yasuko Kitaoa ; Osamu Horia ; d ; osamuh3@staff.kanazawa-u.ac.jp" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATF6α ; Kainate ; Neuronal death ; UPR ; Ca2+
- 刊名：Neurochemistry International
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：67-74
- 全文大小：2534 K
文摘
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The unfolded protein response was activated both in neurons and in glial cells after injection of kainate into the mouse hippocampus.
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Kainate caused a more profound neuronal death in the CA3 region of Atf6α−/− mice than in that of wild type mice.
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Enhanced neuronal death in Atf6α−/− mice was associated with impaired Ca2+ homeostasis and hyperactivity in neurons.