On the mechanism of action of GTP-transforming enzymes

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• 作者：Dufton ; Mark J. ; Gibson ; Colin L. ; Pitt ; Andrew R. ; Athmani ; Salah ; Suckling ; Colin J.
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：1997
• 出版时间：April 8, 1997
• 年：1997
• 卷：7
• 期：7
• 页码：779-784
• 全文大小：385 K

文摘

Mechanisms for the ring conversion of GTP into cofactor precursors by GTP cyclohydrolases and molybdopterin synthase are proposed and discussed in the context of the crystal structure of the GTP cyclohydrolase I - 2′-deoxy-GTP complex. The mechanisms suggest that common features of acid-base catalysis may underly the reactions catalysed in all three cases.