Immunoexpression of BMP-2 and BMP-4 and their receptors, BMPR-IA and BMPR-II, in ameloblastomas and adenomatoid odontogenic tumors

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• 作者：Marcelo Anderson Barbosa Nascimento ; DDS ; MSc ; PhD Student^a ; Cassiano Francisco Weege Nonaka ; DDS ; PhD^b ; Carlos Augusto Galv&atilde ; o Barboza ; DDS ; PhD^a ; Roseana de Almeida Freitas ; DDS ; PhD^a ; Le&atilde ; o Pereira Pinto ; DDS ; PhD^a ; Lé ; lia Batista de Souza ; DDS ; PhD^a ; ^{leliabsouza@gmail.com}
• 关键词：Ameloblastoma ; Adenomatoid odontogenic tumor ; Bone morphogenetic proteins ; Immunohistochemistry
• 刊名：Archives of Oral Biology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：73
• 期：Complete
• 页码：223-229
• 全文大小：2959 K
• 卷排序：73

文摘

We analyzed the expression of BMPs-2 and -4 and their receptors (BMPR-IA and BMPR-II) in SAs, UAs, and AOTs. BMP-2, BMP-4, BMPR-IA and BMPR-II were detected in all cases studied. BMPs-2 and -4 and their receptors play an important role in the differentiation and development of ameloblastomas and AOTs. These proteins may not explain the different biological behaviors of these lesions. Alterations in the regulatory mechanisms of BMPs may contribute to their overexpression in ameloblastomas and AOTs.