The Use of Oxybutynin for Treating Axillary Hyperhidrosis

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• 作者：Nelson Wolosker¹ ; ^{nwolosker@yahoo.com.br} ; José ; Ribas Milanez de Campos² ; Paulo Kauffman¹ ; Samantha Neves¹ ; Marco Antonio Munia³ ; Fá ; bio BiscegliJatene² ; Pedro Puech-Le&atilde ; o¹
• 刊名：Annals of Vascular Surgery
• 出版年：2011
• 出版时间：November, 2011
• 年：2011
• 卷：25
• 期：8
• 页码：1057-1062
• 全文大小：213 K

文摘

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Background

To evaluate the effectiveness and patient satisfaction with the use of oxybutynin for treating axillary hyperhidrosis in a large series of patients.

Methods

One hundred two patients with axillary hyperhidrosis were treated with oxybutynin. During the first week, patients received 2.5 mg of oxybutynin once a day in the evening. From the 8th to the 42nd day, they received 2.5 mg twice a day, and from the 43rd day to the end of the 12th week, they received 5 mg twice a day. All of the patients underwent two evaluations: before and after (12 weeks) the oxybutynin treatment, using a clinical questionnaire; and a clinical protocol for quality of life (QOL).

Results

More than 80 % of the patients experienced an improvement in axillary hyperhidrosis; 36.3 % of them presented a great improvement, and half of the patients showed improvements at all hyperhidrosis sites. Most of the patients showed improvements in the QOL (67.5 % ). The patients with very poor QOL before the treatment presented greater satisfaction levels after treatment. The side effects were minor, dry mouth being the most frequent (73.5 % ).

Conclusions

Oxybutynin is a good alternative to sympathectomy. It presents good results and improves QOL without the side effects of sympathectomy.