Aberrant hippocampal Atp8a1 levels are associated with altered synaptic strength, electrical activity, and autistic-like behavior
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- 作者：Daniel J. Kerra ; Alexandra Marsilloa ; 1 ; Sara R. Guarigliaf ; 1 ; Tatyana Budylina ; Rodina Sadekd ; Silvia Menkesd ; Abha Chauhang ; Guang Y. Wend ; g ; Daniel P. McCloskeye ; d ; Andrzej Wieraszkoc ; d ; Probal Banerjeea ; b ; d ; probal.banerjee@csi.cuny.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Autism ; Atp8a1 ; Flippase ; Synaptic strength ; TEM ; Lenti-virus
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：1862
- 期：9
- 页码：1755-1765
- 全文大小：2417 K
文摘
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IIncreased Atp8a1 expression in the hippocampus and temporal cortex of juvenile patients with autism.
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Lentiviral – transduced Atp8a1 overexpression at p6 elicits autistic-like sociability behavior in adult mice
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Mice deficient in Atp8a1 display normal sociability behavior.
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Altered expression of Atp8a1 yield mice that display decreased excitatory synapses in the hippocampal CA1 region
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The Atp8a1 + mice may serve as an animal model for autism.