Critical examination of a correlation between brain gamma-aminobutyric acid (GABA) concentrations and a personality trait of extroversion in healthy volunteers as measured by a 3 Tesla proton magnetic resonance spectroscopy study
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- 作者：Naoki Goto ; Reiji Yoshimura ; Junji Moriya ; Shingo Kakeda ; Kenji Hayashi ; Nobuhisa Ueda ; Atsuko Ikenouchi-Sugita ; Wakako Umene-Nakano ; Norihiro Oonari ; Yukunori Korogi ; Jun Nakamura
- 关键词：Gamma-aminobutyric acid ; Magnetic resonance spectroscopy ; Personality ; NEO-FFI
- 刊名：Psychiatry Research: Neuroimaging
- 出版年：2010
- 出版时间：30 April 2010
- 年：2010
- 卷：182
- 期：1
- 页码：53-57
- 全文大小：429 K
文摘
We hypothesized that brain gamma-aminobutyric acid (GABA) levels are associated with neuroticism, a trait associated with depression and anxiety disorders. We examined the correlation between brain GABA concentrations and the five factors included in the NEO Five-Factor Inventory (NEO-FFI) in healthy volunteers using magnetic resonance spectroscopy (MRS) at 3 T. Forty-one healthy subjects (21 males, 20 females; age: 35±7 years) were enrolled in this study. Each subject underwent a 3 T 1H-MRS study with a MEGA-PRESS sequence. Spectroscopy voxels (3 cm × 3 cm × 3 cm) were placed in the frontal lobe and the parieto-occipital lobe. A negative correlation was found between the GABA/creatine ratios in the frontal lobe and scores of extroversion on the NEO-FFI. These results suggest that GABAergic neurons are related to personality traits of healthy subjects.