- 作者：Mariko Yoshinaga ; Natsuko Toda ; Yuki Tamura ; Shouko Terakado ; Mai Ueno ; Kie Otsuka ; Atsushi Numabe ; Yukari Kawabata ; Yoshio Uehara
- 关键词：Miso ; Plant fibers ; Salt-induced hypertension ; Kidney ; Dahl rats
- 刊名：Nutrition
- 出版年：2012
- 出版时间：September, 2012
- 年：2012
- 卷：28
- 期：9
- 页码：924-931
- 全文大小：1095 K
Objective
We investigated the effects of long-term miso soup drinking on salt-induced hypertension in Dahl salt-sensitive (Dahl S) rats.Methods
Dahl S rats were divided into four groups that consumed 1) water, 2) a 0.9 % NaCl solution, 3) a 1.3 % sodium NaCl solution, or 4) miso soup containing 1.3 % NaCl. They were followed for 8 wk. Systolic blood pressure and hypertensive organ damage were determined.
Results
Systolic blood pressure increased in an age- and dose-dependent manner in Dahl S rats drinking salt solutions. The systolic blood pressure increase was significantly less in the Dahl S rats that drank miso soup, although the ultimate cumulative salt loading was greater than that in the Dahl S rats given the 1.3 % NaCl solution. This blood pressure decrease was associated with a morphologic attenuation of glomerular sclerosis in the kidney and collagen infiltration in the heart. Urinary protein excretions were less in the miso group than in the rats given the 1.3 % NaCl solution. The fractional excretion of sodium was increased and that of potassium was decreased in Dahl S rats given the 1.3 % NaCl solution, and these effects were reversed in rats given miso soup toward the values of the control.
Conclusion
We found that long-term miso soup drinking attenuates the blood pressure increase in salt-induced hypertension with organ damage. This may be caused by a possible retardation of sodium absorption in the gastrointestinal tract or by the direct effects of nutrients in the miso soup from soybeans. The decrease was associated with decreases in cardiovascular and renal damage.