Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer

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• 作者：Barbara Jung¹ ; ^{bjung@uic.edu} ; Jonas J. Staudacher¹ ; Daniel Beauchamp²
• 关键词：Transforming Growth Factor β ; Activin ; Colon Cancer
• 刊名：Gastroenterology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：152
• 期：1
• 页码：36-52
• 全文大小：1804 K
• 卷排序：152

文摘

Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to regulate proliferation, differentiation, adhesion, migration, and other functions in many cell types. A high percentage of colorectal tumors contain mutations that disrupt TGF-β family member signaling. We review how TGF-β family member signaling is altered during development of colorectal cancer, models of study, interaction of pathways, and potential therapeutic strategies.