Impaired auditory processing and altered structure of the endbulb of Held synapse in mice lacking the GluA3 subunit of AMPA receptors

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• 作者：Sofí ; a Garcí ; a-Herná ; ndez^a ; Manabu Abe^b ; Kenji Sakimura^b ; Marí ; a E. Rubio^a ; ^c ; ^d ; ^mer@pitt.edu
• 关键词：Auditory brainstem ; Cochlear nucleus ; Endbulb of Held synapses ; Ultrastructure ; Postsynaptic density ; Auditory experience
• 刊名：Hearing Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：344
• 期：Complete
• 页码：284-294
• 全文大小：2981 K
• 卷排序：344

文摘

The lack of GluA3 leads to decreased ABR peak amplitudes, increased latency of peak 2 and early onset hearing loss. The number and size of PSDs in the synapse of the auditory nerve on bushy cells is reduced in GluA3-KO mice. The absence of GluA3 hinders ABR threshold recovery after transient sound reduction.