Dopamine D1 receptor activation improves PCP-induced performance disruption in the 5C-CPT by reducing inappropriate responding
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- 作者：S.A. Barnesa ; sabarnes@ucsd.edu" class="auth_mail" title="E-mail the corresponding author ; J.W. Younga ; b ; S.T. Batec ; J.C. Neilld
- 关键词：Schizophrenia ; Attention ; Phencyclidine ; Cognition ; Dopamine D1 receptors
- 刊名：Behavioural Brain Research
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：300
- 期：Complete
- 页码：45-55
- 全文大小：2141 K
文摘
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Repeated PCP administration induced robust deficits in 5C-CPT performance.
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Pre-treatment with dopamine D1 receptor partial agonist, SKF 38393, partially attenuated PCP-induced deficits.
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Augmenting dopamine D1 receptors improved PCP-induced deficits by reducing inappropriate responding.