Role of ageing and coronary atherosclerosis in the development of cardiac fibrosis in the rabbit
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- 作者：Orlandi ; Augusto ; Francesconi ; Arianna ; Marcellini ; Marcella ; Ferlosio ; Amedeo ; Spagnoli ; Luigi Giusto
- 关键词：Ageing ; Atherosclerosis ; Extracellular matrix ; Remodeling ; Endothelial function
- 刊名：Cardiovascular Research
- 出版年：2004
- 出版时间：December 1, 2004
- 年：2004
- 卷：64
- 期：3
- 页码：544-552
- 全文大小：700 K
文摘
Myocardial fibrosis contributes to the impairing of cardiac function and characterizes ageing, but is also a consequence of atherosclerotic ischemic disease. Since atherosclerosis is a slow progressive disease, which prevails in elderly populations, the aim of this study was to distinguish the contribution of ageing and atherosclerosis to cardiac fibrosis.