Cell of Origin Links Histotype Spectrum to Immune Microenvironment Diversity in Non-small-Cell Lung Cancer Driven by Mutant Kras and Loss of Lkb1

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• 作者：Ashwini S. Nagaraj¹ ; ⁵ ; Jenni Lahtela¹ ; ⁵ ; Annabrita Hemmes¹ ; Teijo Pellinen¹ ; Sami Blom¹ ; Jennifer R. Devlin¹ ; Kaisa Salmenkivi² ; Olli Kallioniemi¹ ; ⁴ ; Mikko I. M&auml ; yr&auml ; np&auml ; &auml ; ² ; ³ ; Katja N&auml ; rhi¹ ; Emmy W. Verschuren¹ ; ⁶ ; ^{emmy.verschuren@helsinki.fi}
• 关键词：non-small-cell lung cancer ; Kras ; Lkb1 ; cell-of-origin ; club cell ; immune microenvironment ; tumor-associated neutrophils ; adenosquamous ; histopathology
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：18
• 期：3
• 页码：673-684
• 全文大小：3899 K
• 卷排序：18

文摘

Cell of origin crucially defines tumor proliferation and the histopathology spectrum CC10+ cells are the predominant progenitors of ASC tumors in Kras;Lkb1 mice CC10+ cells give rise to pure mucinous and acinar adenocarcinoma histotypes ASCs exhibit a histotype-specific immunosuppressive microenvironment