Vacuolating cytotoxin A (VacA) - A multi-talented pore-forming toxin from Helicobacter pylori
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- 作者：Muhammad Junaida ; b ; juniphdr@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Aung Khine Linnb ; aung.k.lynn@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Mohammad Bagher Javadib ; mohammad.jav@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author ; Sarbast Al-Gubareb ; sarbastem@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Niaz Alic ; niazpharmacist@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Gerd Katzenmeierb ; katzenmeier.ger@mahidol.ac.th" class="auth_mail" title="E-mail the corresponding author
- 关键词：Helicobacter pylori ; Vacuolating cytotoxin VacA ; Virulence factor ; Pore-forming toxin ; Structure
- 刊名：Toxicon
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：118
- 期：Complete
- 页码：27-35
- 全文大小：828 K
文摘
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Vacuolating cytotoxin VacA is an important virulence factor of H. pylori.
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Main activity of VacA is the formation of ion channels in membranes.
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VacA induces apoptosis by a yet incompletely characterized mechanism.
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A compilation of findings focused on structure-function relations is presented.