Anti-inflammatory and neuroprotective effects of auraptene, a citrus coumarin, following cerebral global ischemia in mice
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- 作者：Satoshi Okuyama ; sokuyama@cc.matsuyama-u.ac.jp ; Sona Minami ; Naoko Shimada ; Nahomi Makihata ; Mitsunari Nakajima ; Yoshiko Furukawa
- 关键词：Auraptene ; Global cerebral ischemia ; Hippocampus ; Anti-inflammation ; COX-2 ; Neuroprotection
- 刊名：European Journal of Pharmacology
- 出版年：2013
- 出版时间：15 January, 2013
- 年：2013
- 卷：699
- 期：1-3
- 页码：118-123
- 全文大小：1204 K
文摘
Cerebral ischemia causes delayed neuronal cell death in the hippocampus resulting in sequential cognitive impairments. Hyper-activated inflammation following ischemia is one of the etiologies for delayed neuronal cell death. In the present study, using a transient global ischemia mouse model, we showed that auraptene (AUR), a citrus coumarin, effectively inhibited microglia activation, cyclooxygenase-2 expression by astrocytes, and neuronal cell death in the hippocampus following ischemic insults. These results suggest that AUR acts as a neuroprotective agent in the ischemic brain, which may be mediated by suppression of the inflammatory response.