Human placental cell and tissue uptake of doxorubicin and its liposomal formulations
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- 作者：Suvi K. Soininen1 ; karoliina.soininen@uef.fi" class="auth_mail" title="E-mail the corresponding author ; Jenni K. Repo1 ; Vesa Karttunen ; Seppo Auriola ; Kirsi H. Vä ; hä ; kangas ; Marika Ruponen
- 关键词：Pregnancy ; Doxorubicin ; Liposome ; Doxil ; Human placental perfusion ; BeWo cells
- 刊名：Toxicology Letters
- 出版年：2015
- 出版时间：3 December 2015
- 年：2015
- 卷：239
- 期：2
- 页码：108-114
- 全文大小：496 K
文摘
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Human placental cell and tissue uptake of doxorubicin was significant.
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Doxorubicin crossed placenta at low levels within 4-h human placental perfusion.
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Pegylated liposomal doxorubicin was weakly taken up by human placental cells.
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Pegylated liposomal doxorubicin did not cross human placenta in 4-h perfusion.