Synthesis of novel deuterium labelled derivatives of N

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• 作者：Merja R. Hä ; kkinen ; Tuomo A. Keinä ; nen ; Alex R. Khomutov ; Seppo Auriola ; Janne Weisell ; Leena Alhonen ; Juhani Jä ; nne ; Jouko Vepsä ; lä ; inen
• 关键词：Polyamines ; Deuterated polyamines ; Deuterated ; N-Alkylated polyamine analogues
• 刊名：Tetrahedron
• 出版年：2009
• 出版时间：10 January 2009
• 年：2009
• 卷：65
• 期：2
• 页码：547-562
• 全文大小：625 K

文摘

Novel di-, tetra- and octadeuterated derivatives of mono-N-alkylated diaminopropanes, spermidines, spermines, symmetrically bis-N-alkylated spermines and unsymmetrically bis-N-alkylated spermines were synthesized. Deuterium labels were introduced into the RHNCH₂CH₂CN intermediate either by exchanging the protons next to the nitrile group under basic conditions with D₂O–EtOD mixture or/and by reducing the nitrile group to a CD₂–NH₂ fragment with LiAlD₄.