Proteomic Analysis of Pemphigus Autoantibodies Indicates a Larger, More Diverse, and More Dynamic Repertoire than Determined by B Cell Genetics

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• 作者：Jing Chen¹ ; ⁵ ; ⁶ ; Qi Zheng¹ ; ⁵ ; Christoph M. Hammers¹ ; Christoph T. Ellebrecht¹ ; Eric M. Mukherjee¹ ; Hsin-Yao Tang² ; Chenyan Lin¹ ; Huijie Yuan¹ ; Meng Pan¹ ; ⁷ ; Jana Langenhan³ ; Lars Komorowski³ ; Don L. Siegel⁴ ; Aimee S. Payne¹ ; John R. Stanley¹ ; ⁸ ; ^{jrstan@mail.med.upenn.edu}
• 关键词：pemphigus ; autoantibodies ; proteomics ; B cell ; autoimmunity ; serum antibodies
• 刊名：Cell Reports
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：237-247
• 全文大小：1556 K
• 卷排序：18

文摘

Proteomic analysis of serum-antigen-specific human autoantibodies Autoimmune B cell repertoire poorly reflects serum autoantibody repertoire No convergence of autoantibody response among pemphigus patients The same circulating autoantibody clones may persist for several years