CD26/DPPIV inhibition alters the expression of immune response-related genes in the thymi of NOD mice
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- 作者：Marí ; a Teresa Juliá ; na ; b ; 1 ; Nú ; ria Alonsoa ; b ; g ; 1 ; Roger Colobranc ; Alex Sá ; ncheze ; f ; Antoni Miñ ; arroe ; Irma Pujol-Autonelld ; Jorge Carrascald ; Silvia Rodrí ; guez-Ferná ; ndezd ; Rosa Marí ; a Ampudiad ; Marta Vives-Pid ; g ; Manel Puig-Domingoa ; b ; g ; h ; mpuigd@igtp.cat" class="auth_mail" title="E-mail the corresponding author
- 关键词：Type 1 diabetes prevention ; DPPIV/CD26 inhibition ; DNA microarray analysis ; β-cell autoantigens expression ; NOD mice ; Gene expression
- 刊名：Molecular and Cellular Endocrinology
- 出版年：2016
- 出版时间：5 May 2016
- 年：2016
- 卷：426
- 期：Complete
- 页码：101-112
- 全文大小：1607 K
文摘
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Treatment with DPPIV inhibitors may contribute to the prevention of T1D.
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Expression of immune –related genes is modified in the thymi of NOD mice by MK626.
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MK626 treatment increases the expression of genes involved in central tolerance.
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DPPIV inhibitor treatment does not alter β-cell autoantigens and Aire expression in TECs.