Bioinformatics evaluation of the possibility of heat shock proteins as autoantigens in multiple sclerosis based on molecular mimicry hypothesis
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- 作者：Safa Ansari Qeshmia ; Fatemeh Dabbagha ; c ; Afshin Borhani Haghighib ; Younes Ghasemia ; ghasemiy@sums.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Autoimmunity ; Heat shock proteins (HSPs) ; Immunoinformatics ; Molecular mimicry ; Multiple Sclerosis (MS)
- 刊名：Journal of Neuroimmunology
- 出版年：2016
- 出版时间：15 June-15 July 2016
- 年：2016
- 卷：295-296
- 期：Complete
- 页码：100-121
- 全文大小：7379 K
文摘
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The molecular mimicry hypothesis of self and foreign HSPs in MS is assessed.
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The study proposes a prediction of microorganism's role in pathogenesis of MS.
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The immunodominant epitopes of microorganisms's HSPs are identified.
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The obtained results may be beneficial for developing altered peptide ligands (APLs).
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Results may be useful for identification of infectious triggers and antigens in MS.