刊名:Biochemical and Biophysical Research Communications
出版年:2017
出版时间:22 January 2017
年:2017
卷:482
期:4
页码:1334-1340
全文大小:1995 K
卷排序:482
文摘
Lysosomal proteolysis attenuates crizotinib-induced apoptosis in NSCSC cells. Crizotinib-induced apoptosis is enhanced by inhibition of lysosomal proteolysis. MCL1 degradation is suppressed by chaperone-mediated autophagy (CMA). CMA-mediated stabilization of MCL1 was observed in several NSCLC cell lines. CMA inhibition and ABT-263 efficiently induces apoptosis in NSCLC cells.