Characterization of Ambra1 in asexual cycle of a non-vertebrate chordate, the colonial tunicate Botryllus schlosseri, and phylogenetic analysis of the protein group in Bilateria
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- 作者：Fabio Gasparinia ; 2 ; fabio.gasparinini@unipd.it" class="auth_mail" title="E-mail the corresponding author ; Tatjana Skoboa ; 2 ; tatjana.skobo@bio.unipd.it" class="auth_mail" title="E-mail the corresponding author ; Francesca Benatoa ; 1 ; benato@cutech.it" class="auth_mail" title="E-mail the corresponding author ; Giorgia Gioacchinib ; gigioacc@mta01.univpm.it" class="auth_mail" title="E-mail the corresponding author ; Ayelet Voskoboynikc ; ayeletv@stanford.edu" class="auth_mail" title="E-mail the corresponding author ; Oliana Carnevalib ; carneval@mta01.univpm.it" class="auth_mail" title="E-mail the corresponding author ; Lucia Mannia ; 3 ; lucia.manni@unipd.it" class="auth_mail" title="E-mail the corresponding author ; Luisa Dalla Vallea ; 3 ; luisa.dallavalle@unipd.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：AMBRA1 ; autophagy/beclin 1 regulator 1 ; ATG ; autophagy-related proteins ; Bcl-2 ; B-cell lymphoma 2 ; BECN1 ; Beclin 1 ; autophagy-related ; Bif-1 ; bax-interacting factor-1 ; BLAST ; Basic Local Alignment Search Tool ; BLAT ; BLAST Like Alignment Tool ; cDNA ; complementary DNA ; DLC1 ; Dynein light chain 1 ; EMBL ; European Molecular Biology Laboratory ; EST ; expressed sequence tags ; KATNB1 ; Katanin P80 (WD Repeat Containing) Subunit B 1 ; IDPs ; Intrinsically Disordered Proteins ; mRNA ; messenger RNA ; PCR ; polyme
- 刊名：Molecular Phylogenetics and Evolution
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：46-57
- 全文大小：2925 K
文摘
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We characterized the first ambra1 transcript in an invertebrate chordate: B. schlosseri.
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Its expression has been quantified all along the asexual life cycle of B. schlosseri.
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We identified Wdr5 and Katnb1 as proteins evolutionarily related to Ambra1.
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We resolved that ambra1 evolved at least before the radiation of Bilateria.
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Ancient duplications of WD40 repeats are related to a N-terminal domain.