Metabotropic glutamate receptor 2/3 density and its relation to the hippocampal neuropathology in a model of temporal lobe epilepsy in rats
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- 作者：Idrish Alia ; idrish.ali@uantwerpen.be" class="auth_mail" title="E-mail the corresponding author ; Stephanie Boetsa ; Pieter Janssensa ; Annemie Van Eetveldta ; Halima Amhaoula ; Xavier Langloisb ; Stefanie Dedeurwaerderea ; stefanie.dedeurwaerdere@uantwerpen.be" class="auth_mail" title="E-mail the corresponding author
- 关键词：Epilepsy ; Metabotropic glutamate receptors ; Autoradiography ; Hippocampal neuropathology
- 刊名：Epilepsy Research
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：127
- 期：Complete
- 页码：55-59
- 全文大小：1063 K
文摘
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Reduced mGluR2/3 binding in limbic regions at acute (2 day) and latent periods (7 day) after SE.
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Increased mGluR2/3 binding in widely distributed brain areas at late latent phase (14 day).
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Reduced mGluR2/3 in stratum lacunosum moleculare during chronic epilepsy (42 & 84 day).
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MGluR 2/3 binding in CA1 region correlated negatively with cell loss in the hippocampus.