Enteroendocrine cells are a potential source of serum autotaxin in men
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- 作者：Ruth Boliera ; Dagmar Tolenaarsa ; Andreas E. Kremerb ; Job Sarisa ; Albert Paré ; sd ; Joanne Verheijc ; Piter J. Bosmaa ; Ulrich Beuersa ; Ronald P.J. Oude Elferinka ; r.p.oude-elferink@amc.uva.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：5-HT ; serotonin ; AD ; atopic dermatitis ; ATX ; autotaxin ; ALT ; alanine transaminase ; ALP ; alkaline phosphatase ; ANOVA ; analysis of variance ; AST ; aspartate transaminase ; AUC ; area under the curve ; CA ; cholic acid ; BAT ; brown adipose tissue ; BDL ; bile duct ligation ; CCK ; cholecystokinin ; cDNA ; complementary deoxyribonucleic acid ; CgA ; chromogranin A ; DCLK1 ; double cortin-like kinase 1 ; EEC ; enteroendocrine cell ; ELISA ; enzyme-linked immunosorbent assay ; ENPP2 ; ectonucleotide pyrophosphatase/phospho
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1862
- 期：4
- 页码：696-704
- 全文大小：1368 K
文摘
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During cholestasis ATX protein content rather than enzymatic activity increases.
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Cholestasis did not affect rATX clearance in mice.
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ATX is expressed in human but not murine intestinal enteroendocrine cells.
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In cholestatic mice, ATX activity is only moderately increased compared to humans.