The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors
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- 作者：Janet L. Fisher ; jfisher@uscmed.sc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Kainate receptors ; Recombinant ; Auxiliary subunits ; Ionotropic ; Glutamate receptors ; Neto
- 刊名：Neuropharmacology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：99
- 期：Complete
- 页码：471-480
- 全文大小：1263 K
文摘
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Both Neto1 and Neto2 increase glutamate sensitivity of GluK1 receptors.
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Neto1 slows onset of desensitization of GluK1 receptors in response to sub-maximal but not saturating glutamate levels.
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Neto2 slows onset of desensitization of GluK1 and GluK2 receptors at all levels of activation.
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The differing effects of Neto1 and Neto2 at GluK1 receptors are associated with their extracellular CUB domains.