Predictive factor and clinical consequence of left bundle-branch block after a transcatheter aortic valve implantation

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• 作者：Takahiko Nishiyama ; ^{ntakahiko914@gmail.com} ; Sho Tanosaki ; Makoto Tanaka ; Ryo Yanagisawa ; Fumiaki Yashima ; Takehiro Kimura ; Takahide Arai ; Hikaru Tsuruta ; Mitsushige Murata ; Yoshiyasu Aizawa ; Takashi Kohno ; Yuichiro Maekawa ; Kentaro Hayashida ; Seiji Takatsuki ; Keiichi Fukuda
• 关键词：Aortic stenosis ; Transcatheter aortic valve implantation ; Pacemaker ; Left bundle-branch block
• 刊名：International Journal of Cardiology
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：227
• 期：Complete
• 页码：25-29
• 全文大小：397 K
• 卷排序：227

文摘

Atrioventricular conduction disturbances can develop after transcatherter aortic valve implantations (TAVIs) with balloon-expandable valves because the conduction system exists adjacent to the aortic valve. However, the clinical consequence of patients with new onset conduction disturbances is not clear.ObjectiveThis study aimed to assess the incidence and progress of new-onset conduction disturbances following TAVIs and the cardiac function evaluated by echocardiography.MethodsThis study consisted of 90 consecutive patients that underwent TAVIs with Edwards SAPIEN XT valves in a single center. Atrioventricular conduction system disturbances were assessed by electrocardiography and echocardiography up to 6 months post TAVI.ResultsTwenty patients (22%) developed new onset complete left bundle branch block (CLBBB) or received pacemaker implantations (PMIs) during the follow-up. At 6 months after the procedure, 4 patients underwent PMIs for complete AV block (CAVB), and 4 patients had persistent CLBBB. Those that developed CLBBB and AVB had a higher morbidity from hypertension and lower estimated glomerular filtration rate (eGFR). The ECG, TTE, and CT parameters did not differ between the two groups. The ratio of the valve and LVOT area was significantly associated with a higher cumulative risk of events (HR, 3.005; 95% CI, 1.034–8.736; P < 0.05).ConclusionsUp to 20% of patients developed new CLBBB or CAVB and more than half were expected to recover. However, it required attention because approximately 40% were persistent. The ratio of the valve to LVOT area was an independent predictor.